5 ways grant-funded research at Brown is changing and saving lives

Every day, researchers at Brown are working on groundbreaking discoveries—made possible through federal and private grant funding.

As a leading research university, Brown has a mission to generate global impact through discovery, innovation, and the creation of knowledge. 

From brain science to engineering to public health and beyond, research at Brown takes on complex challenges and unanswered questions every day. Our deeply collaborative approach gives us a unique ability to test innovative ideas, and we seamlessly turn findings into real solutions. As a direct result, lives are changed—and saved. 

Grant funding—whether from federal agencies, like the National Institutes of Health, or corporate and foundation sources—is a major reason that Brown is able to successfully conduct this groundbreaking work. 

From transforming our understanding of health and disease, to fueling medical breakthroughs, to improving approaches to policy and education, here are just five ways that grant-funded research at Brown has a direct impact on our lives today.

1. Translating scientific discovery about the brain into life-changing solutions for serious neurological conditions 

Through research involving Brown scientists and alumni, a brain-computer interface allowed a man with ALS to ‘speak’ again. The system translates brain signals into words, with up to 97% accuracy, making it a major breakthrough for people with severe speech loss. The study is part of the BrainGate clinical trial which is directed by Leigh Hochberg ’90, a professor at the School of Engineering who is also affiliated with the Carney Institute for Brain Science.

Another research team at Brown has been working with 3-D cultures of neural cells, basically functional mini-brains, to study the effects of compression injuries. Though a common type of brain injury—often caused by stroke, tumors, or head trauma—these injuries are difficult to study because their damage develops over time. Led by Diane Hoffman-Kim, an associate professor of neuroscience and engineering, the team has found a way to model compression injuries through these mini-brains, generating life-saving information on how it might be possible to prevent, diagnose, and treat them.

2. Harnessing technology—like artificial intelligence and virtual reality—to transform how we treat disease and mental health disorders

Ying Ma, assistant professor of biostatistics at the School of Public Health, was a co-developer of IRIS, a new AI-powered statistics method that has the potential to improve tissue and disease research. IRIS gives biomedical researchers the ability to view more detailed information about tissue development, disease pathology, and tumor organization. Their study was published in the Nature Methods journal, and the team is hopeful that the method will lead to precision treatment plans. 

And at Brown’s Warren Alpert Medical School, researchers found that an innovative combination of two treatments, virtual reality plus electric brain stimulation, offers a promising treatment for PTSD among military veterans—a condition that has been difficult to treat for this population. Results from their clinical trial showed that participants who received brain stimulation during sessions of virtual reality warzone exposure reported a significant reduction in symptom severity. 

3. Tackling unique challenges facing older adults, from aging to Alzheimer's to climate change

Researchers at Brown are leading a $13 million federal grant to examine the impact of health policies on people with Alzheimer’s. Most health policies are designed and evaluated with “average” patients in mind, without specific consideration for high-cost, high-need populations. The goal of this research will be to address urgent health policy gaps for people with Alzheimer's and related dementias, ultimately leading to improvements in care.

With a $3.8 million grant, researchers from the School of Public Health are establishing a center to study the negative health impacts of climate change on aging populations. The new Climate, Health, and Aging Innovation and Research Solutions for Communities center will have an interdisciplinary approach, incorporating scholarship from public health to environmental science and beyond. The goal will be to improve the resilience of older adults facing the effects of climate change. 

At Brown’s Center on the Biology of Aging, biologists are studying how gut hormones control aging in flies. They’ve discovered how a neuropeptide hormone made in the gut of flies can actually extend their lifespan. The findings have implications for humans—especially in regard to how certain medications that are used to treat obesity and diabetes may affect human aging.

4. Supporting new teachers and advocates for children’s health 

Through grant funding from the Barr Foundation, Brown researchers set out to develop a pilot program to support early-career teachers in four Providence-area public schools. The program provides alumni from Brown’s Master of Arts in Teaching (MAT) graduate program with instructional coaching, professional development, and training in culturally relevant practices. The aim is to help early-career teachers in urban communities thrive and meet the needs of their students. 

Among the focus areas for Brown’s Hassenfeld Child Health Innovation Institute, which receives generous support from the Hassenfeld Foundation, is understanding the impacts of social media on children’s mental health. A 2024 conference brought together researchers, medical professionals, scholars, advocates for parents and children, and policymakers to examine children’s social media use—from the benefits to the challenges to the opportunities for change. 

5. Improving our understanding of the risks associated with substance use and unregulated drug supply

With a $12.3 million federal grant, Brown’s Center for Addiction and Disease Risk Exacerbation is expanding its research on substance misuse and chronic disease. This grant funding will enable the center to expand its research and training and to broaden studies to include participants from across the country and world. Based at the School of Public Health, rather than within the medical school or at a hospital, this center is unique in that it will not only answer biomedical research questions but will also engage behavioral health researchers and health policy scholars—an interdisciplinary approach that will lead to change on many levels. 

A study authored by Rachel Wightman, an associate professor of epidemiology and emergency medicine at Brown, provided a comprehensive analysis of Rhode Island’s unregulated drug supply—revealing the frequency of potentially lethal substances, such as fentanyl and xylazine, in counterfeit pills. The analysis, published in the Journal of the American Medical Association, could help inform treatment conversations and improve patient care.