Transcending the boundaries of AI and science at Brown

A recent Brown+Beyond event welcomed alumni and friends to an engaging discussion with two campus AI leaders, Michael Littman and Brenda Rubenstein.

Brown alumni and parents in the Bay Area recently came together for an event, “Transcending Boundaries: AI + Science,” in San Francisco. 

The evening was part of the Brown+Beyond event series, which offers exclusive opportunities to learn more about the expertise and impact of Brown’s faculty, research, and leadership. 

Aliisa Rosenthal '05, an alum who was an executive at OpenAI in its early days and currently focuses on AI-native companies as General Partner at Acrew Capital, kicked off the event by introducing the two speakers: Michael Littman PhD'96, P'21, University Professor of Computer Science and the inaugural Associate Provost for Artificial Intelligence; and Brenda Rubenstein '07, Director of the Data Science Institute, Professor of Physics, and Vernon K. Krieble Professor of Chemistry.

The thoughtful discussion explored how Brown researchers are leveraging AI's profound potential to advance health and science research, while also navigating the challenges it presents in the classroom and society. 

Alums back at Brown for AI leadership roles

Littman may be Brown’s first Associate Provost for Artificial Intelligence, but his connection to AI at Brown goes back much further. 

“Brown has been engaged in artificial intelligence work for a really long time,” said Littman. “In fact, I got my Ph.D. at Brown in artificial intelligence, graduating in 1996. And I wasn't the first. There was a lot of work going on that was really, really interesting.”

Littman began teaching in Brown’s computer science department in 2012, before leaving for a few years to focus on AI within the federal government. He returned to Brown in 2025 to take on this new leadership role.

Rubenstein graduated from Brown as a chemical physicist with an applied math background, and returned to College Hill about a decade ago. Now, leading the Data Science Institute, her aim is to help people across the campus community access and understand data, including through analysis of AI and machine learning.

“I came back to Brown because it was an incredible experience to think across a wide variety of different disciplines,” said Rubenstein. “I very specifically decided to attend Brown—perhaps as many of you did as students—because I was interested in crossing the social sciences with a lot of the hard sciences.”

Brown’s collaborative approach to exploring AI’s impact on research 

During the panel, Littman and Rubenstein discussed ways that AI has revolutionized health and science research, as well as how Brown’s collaborative culture makes it a uniquely effective place for exploring AI. 

Rubenstein described how AI allows researchers to accelerate computational science and test hypotheses much more quickly, potentially shaving years off of research projects. 

“What AI really lets us do is not only think of ideas, but actually get a first test,” explained Rubenstein. “It might not be the most accurate thing. It might not tell you the answer for everything. But it really lets you say: Here's a hypothesis, would it actually make any sense to put it in the wild?”

She went on to specifically dive into how AI is supporting RNA researchers at Brown. “We're amassing huge amounts of RNA data. It's all dedicated to understanding the structural properties of RNA. And so that's an area where AI can really go in and tell us things that we never understood before.”

As AI reframes how researchers approach difficult questions about science, Littman sees Brown’s interdisciplinary academic style as a unique strength in this pursuit. 

“Brown uniquely excels at collaboration across boundaries," he said. “The attitude on campus is: Let's come together to think about global issues in new ways. And I think that's extremely critical in this AI era—partly because, now that AI is everywhere, the way to make progress, the way to actually do things that are important, is to reach across and make these connections. And I think Brown is really well-situated for that.”

Rubenstein provided a specific example of Brown’s cross-campus collaboration. She explained that the deputy director at the Data Science Institute is Holly Case, a professor of history. 

“If you go to other institutions, they'd probably be like, ‘no way, we're never having a historian be a deputy director of data science, why does that even make sense?’” said Rubenstein. “But Holly's our deputy director because she brings in the knowledge of humanistic thought—thinking about how AI would actually impact the course of history.”

Addressing AI challenges in the classroom 

The conversation also covered the challenges that come with AI, especially within teaching.

In chemistry and physics, Rubenstein wants to make sure students still get exposure to the depths of the mechanics behind the processes and equations they’re working with. “That's the thing that I personally worry about in the classroom: How do you build up that exposure without people always using AI to try to stitch things together or to quickly learn things?” she said. “Because it takes time. It took me eight years to really understand the world of physics, and I still don't understand it, right? So if people are trying to get that eight years in two hours, they just aren't going to be able to come up with the next best thing. It's going to be much harder and slower to do.”

Littman expressed similar concerns within computer programming. “We need to teach our students how to program—that's part of being a computer scientist,” he said. “But how do we do that? Because the use of these tools is really undermining students’ ability to engage deeply with the underlying cognitive process.”

Both speakers expressed that there are also encouraging signs for how AI is reshaping education. Rubenstein pointed out that AI has made her approach to teaching even more personal. 

“It's actually making some aspects of education much more intimate than they were before,” she explained. “I make sure that I have formative conversations with students. I don't just say, come back to me with a project in two months. It's more of a back-and-forth process now. How are you sculpting your ideas? How is it shaping up? What do you think is going to be the future of that path? There are a lot of things that are changing like that in this landscape of AI and machine learning.”

Littman and Rubenstein made clear throughout this conversation that there is a great deal of discovery still to come regarding the complexities of AI in science, research, and the classroom. And Brown researchers, faculty, and students are at the forefront of it all, leading the way with skills that are—irreplaceably—very human.